NADogen®

Recommended dose

Adults take 2 capsules 1 time per day or as advised by a health care practitioner.

Cautions:

Do not use this product if you are pregnant or breastfeeding. Some people may experience gastrointestinal upset and/or diarrhea. Stop use if hypersensitivity/allergy occurs.

Store in dry, cool place away from sunlight.

Do not use if seal is broken. Keep out of reach of children. Keep sealed, store in a cool, dry place at 15–25ºC.

References:

• Hector Rodriguez Cetina Biefer1 et al., Aspects of Tryptophan and Nicotinamide Adenine Dinucleotide in Immunity: A New Twist in an Old Tale, International Journal of Tryptophan Research  2017 Volume 10: 1–8
• Ryan W. Dellinger et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study, npj Aging and Mechanisms of Disease (2017)0:17
• Shin-Ichiro Imai and  Leonard Guarente; t takes two to tango: NAD+ and sirtuins in aging/longevity control; NPJ Aging Mech Dis. 2016 Aug 18;2:16017
• Na Xie et al,  NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential, Signal Transduction and Targeted Therapy volume 5, Article number: 227 (2020)
• Bernard Cuenoud et al. Effect of circadian rhythm on NAD and other metabolites in human brain, Frontiers in  Physiology 09 November 2023
• Daniel C Levine et al.  NAD+ Controls Circadian Reprogramming Through PER2 Nuclear Translocation to Counter Aging, Mol Cell. 2020 June 04; 78(5): 835–849.
• Daniel C. Levine et al. Circadian NAD(P)(H) cycles in cell metabolism, Seminars in Cell & Developmental Biology Volume 126, June 2022, Pages 15-26
• Nichola J Conlon, The Role of NAD+ in Regenerative Medicine, Plast Reconstr Surg. 2021 Sep 28;150
• Tooba Iqbal and  Takashi Nakagawa , The therapeutic perspective of NAD+ precursors in age-related diseases, Biochemical and Biophysical Research Communications, Volume 702, 2 April 2024
• Sophie Lautrup et al., NAD+ in Brain Aging and Neurodegenerative Disorders, Cell Metab 2019 October 01
• Shin-ichiro Imai  and Leonard Guarente, NAD+ and sirtuins in aging and disease, Trends in Cell Biology, Volume 24, Issue 8, August 2014,
• Rashmi Patil and Urmila Aswar, Role of Pterostilbene in Maetabolic Diseass through SIRT1 pathway, Turkish Journal of Agriculture – Food Science and Technology, 2021)
• Giusy Russomanno et al. The anti-ageing molecule sirt1 mediates beneficial effects of cardiac rehabilitation, Immunity and Ageing , 2017 14:7
• Amanda J. Stock  and Yie Liu, NAD-Linked Metabolism and Intervention in Short Telomere Syndromes and Murine Models of Telomere Dysfunction, Frontiers in Aging, October 2021, Volumer 2, Article 785171
• Amanda J. Stock et al. Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo, GeroScience, Volume 45, pages 2213–2228, (2023)
• Hector Rodriguez Cetina Biefer et al. Aspects of Tryptophan and Nicotinamide Adenine Dinucleotide in Immunity: A New Twist in an Old Tale, Int J Tryptophan Res. 2017 Jun 14