If you are reading this blog, chances are that you are quite serious about the health and wellness industry. It can be challenging to navigate the abundance of truths and myths, particularly online. Who is providing this health advice? Are there studies on these supplements? How can I trust what they are saying?
That is why at Provita, we wanted to seize this opportunity to demonstrate the places you can turn to find information, especially regarding the current most popular topic and supplement: Nattokinase.
We pride ourselves on backing up our claims on both our supplements and our blogs because that is the true “holistic” way to live.
Briefly, Nattokinase was first discovered in 1987 by Dr. Hiroyuki Sumi, a researcher at the University of Chicago. Dr. Sumi was interested in finding a natural way to prevent blood clots and began studying natto, which has long been known for its health benefits.
He discovered that natto contains an enzyme that is able to break down fibrin, a protein that is involved in the formation of blood clots.
Since this first discovery, there are numerous scientific studies that followed, bringing to life a series of potential benefits of this amazing enzyme:
- Reduces the risk of blood clots: Nattokinase has been shown to break down fibrin, a protein that is involved in the formation of blood clots. This means that nattokinase may reduce the risk of cardiovascular events such as heart attack and stroke.
- Lowers blood pressure: Some studies have found that nattokinase can help lower blood pressure in people with hypertension.
- Reduces inflammation: Nattokinase has been found to have anti-inflammatory properties, which may help to reduce inflammation in the body.
- May have anticancer properties: Some research suggests that nattokinase may have anticancer properties, although further studies are needed to confirm this.
- Supports healthy circulation: By reducing the risk of blood clots and improving blood flow, nattokinase may support healthy circulation in the body.
- Nattokinase can be beneficial for the hardening of the arteries, high blood pressure, hemorrhoids, and varicose veins.
Those are some pretty incredible claims. This list below has live links enabling you to view the research we have used.
We always bring you the most up-to-date, researched-backed information, this is why at the end of our blogs you will see lists of references included.
And while we love to share information about our incredible supplements and ingredients, we always advise you to talk to your healthcare provider prior to starting supplements outside of your regular routine, especially if you have a current health condition or you’re on medication.
You may read our full blog on Nattokinase by clicking here.
Provita’s formulas blend the rich tradition of natural health from cultures around the world with modern scientific research. We’re passionate about using our profound European-inspired clinical research to create the perfect natural health supplements. When given the right combination of nutrients, the body can activate its very own incredible self-healing abilities to actively deal with any issues.
Our products are rooted in science and care and work to optimize the human body, providing you with the building blocks to transform your health.
Success to us means that many can return to the life they once had or begin one that they strive to have. We want to constantly provide innovative new product developments to tackle any health challenges that hold people back.
Our hope is that our products will be easily accessible around the world, providing people with an efficient and fruitful way to live life to its fullest.
List of references:
- Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84(3):139-43. doi: 10.1159/000204692. PMID: 2206859.
- Chen H, McGowan EM, Ren N, Lal S, Nassif N, Shad-Kaneez F, Qu X, Lin Y. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomark Insights. 2018 Jul 5;13:1177271918785130. doi: 10.1177/1177271918785130. PMID: 30013308; PMCID: PMC6043915.
- Kurosawa Y, Nirengi S, Homma T, Esaki K, Ohta M, Clark JF, Hamaoka T. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015 Jun 25;5:11601. doi: 10.1038/srep11601. PMID: 26109079; PMCID: PMC4479826.
- Weng Y, Yao J, Sparks S, Wang KY. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017 Feb 28;18(3):523. doi: 10.3390/ijms18030523. PMID: 28264497; PMCID: PMC5372539.
- Wu H, Wang Y, Zhang Y, Xu F, Chen J, Duan L, Zhang T, Wang J, Zhang F. Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress. Redox Biol. 2020 May;32:101500. doi: 10.1016/j.redox.2020.101500. Epub 2020 Mar 11. PMID: 32193146; PMCID: PMC7078552.
- Li D, Hou L, Hu M, Gao Y, Tian Z, Fan B, Li S, Wang F. Recent Advances in Nattokinase-Enriched Fermented Soybean Foods: A Review. Foods. 2022 Jun 24;11(13):1867. doi: 10.3390/foods11131867. PMID: 35804683; PMCID: PMC9265860.
- Chen H, Chen J, Zhang F, Li Y, Wang R, Zheng Q, Zhang X, Zeng J, Xu F, Lin Y. Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants. Front Cardiovasc Med. 2022 Aug 22;9:964977. doi: 10.3389/fcvm.2022.964977. Erratum in: Front Cardiovasc Med. 2022 Dec 05;9:1076420. PMID: 36072877; PMCID: PMC9441630.
- Jang JY, Kim TS, Cai J, Kim J, Kim Y, Shin K, Kim KS, Park SK, Lee SP, Choi EK, Rhee MH, Kim YB. Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation. Lab Anim Res. 2013 Dec;29(4):221-5. doi: 10.5625/lar.2013.29.4.221. Epub 2013 Dec 20. PMID: 24396387; PMCID: PMC3879341.
- Altaf F, Wu S, Kasim V. Role of Fibrinolytic Enzymes in Anti-Thrombosis Therapy. Front Mol Biosci. 2021 May 28;8:680397. doi: 10.3389/fmolb.2021.680397. PMID: 34124160; PMCID: PMC8194080. 10. Ren NN, Chen HJ, Li Y, Mcgowan GW, Lin YG. [A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia]. Zhonghua Yi Xue Za Zhi. 2017 Jul 11;97(26):2038-2042. Chinese. doi: 10.3760/cma.j.issn.0376-2491.2017.26.005. PMID: 28763875.
- Ren NN, Chen HJ, Li Y, Mcgowan GW, Lin YG. [A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia]. Zhonghua Yi Xue Za Zhi. 2017 Jul 11;97(26):2038-2042. Chinese. doi: 10.3760/cma.j.issn.0376-2491.2017.26.005. PMID: 28763875.