Nicotinamide Adenine Nucleotide (NAD+) can influence many key cellular functions critical for healthy aging.
Mitochondrial dysfunction is a hallmark of metabolic decline during aging. NAD+ is required not only for life but for a long life. It declines with age.
Nadogen® is a complex and unique formulation designed to support the increase of the body’s NAD+ levels.
Features
A complex and unique formulation intended to help the body synthesize NAD+ using three distinct pathways: the de novo pathway, the Preiss–Handler pathway, and the salvage pathway.
- 100% vegan non-GMO formula
- Complex and unique formulation
- High-dose 250 mg of pure NR
- Pterostilbene is added to majorly enhance NAD activity (Imai, 2016)
- Pterostilbene supports Sirtuins activation, an anti-aging element (Guarente, 2014) (Patil, 2021)
- Added Medium Chain Triglycerides (MCT) for increased Pterostilbene overall bio-availability
Benefits
- Helps boost NAD+ levels
- NAD+ Converts to NADH to increase energy production (ATP) at the cellular level and supports cognitive health (such as memory and mental clarity) (NPN 80046177) (Xie 2020)
- Improves sleep by controlling circadian reprogramming (Levine et al. 2020) (Cuenoud et al. 2023) (Levine et al. 2022)
- NAD plays a significant role in the body as an agent for repair and anti-aging (Conlon 2021) (Iqbal 2024) (Lautrup 2019)
- Helps in energy metabolism and cellular energy level maintenance
Did you know?
Energy (ATP) in the mitochondria is produced as a result of the electron shuttle between NAD+ and NADH.
References:
- Hector Rodriguez Cetina Biefer1 et al., Aspects of Tryptophan and Nicotinamide Adenine Dinucleotide in Immunity: A New Twist in an Old Tale, International Journal of Tryptophan Research 2017 Volume 10: 1–8
- Ryan W. Dellinger et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study, npj Aging and Mechanisms of Disease (2017)0:17
- Shin-Ichiro Imai and Leonard Guarente; t takes two to tango: NAD+ and sirtuins in aging/longevity control; NPJ Aging Mech Dis. 2016 Aug 18;2:16017
- Na Xie et al, NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential, Signal Transduction and Targeted Therapy volume 5, Article number: 227 (2020)
- Bernard Cuenoud et al. Effect of circadian rhythm on NAD and other metabolites in human brain, Frontiers in Physiology 09 November 2023
- Daniel C Levine et al. NAD+ Controls Circadian Reprogramming Through PER2 Nuclear Translocation to Counter Aging, Mol Cell. 2020 June 04; 78(5): 835–849.
- Daniel C. Levine et al. Circadian NAD(P)(H) cycles in cell metabolism, Seminars in Cell & Developmental Biology Volume 126, June 2022, Pages 15-26
- Nichola J Conlon, The Role of NAD+ in Regenerative Medicine, Plast Reconstr Surg. 2021 Sep 28;150
- Tooba Iqbal and Takashi Nakagawa , The therapeutic perspective of NAD+ precursors in age-related diseases, Biochemical and Biophysical Research Communications, Volume 702, 2 April 2024
- Sophie Lautrup et al., NAD+ in Brain Aging and Neurodegenerative Disorders, Cell Metab 2019 October 01
- Shin-ichiro Imai and Leonard Guarente, NAD+ and sirtuins in aging and disease, Trends in Cell Biology, Volume 24, Issue 8, August 2014,
- Rashmi Patil and Urmila Aswar, Role of Pterostilbene in Maetabolic Diseass through SIRT1 pathway, Turkish Journal of Agriculture – Food Science and Technology, 2021)
- Giusy Russomanno et al. The anti-ageing molecule sirt1 mediates beneficial effects of cardiac rehabilitation, Immunity and Ageing , 2017 14:7
- Amanda J. Stock and Yie Liu, NAD-Linked Metabolism and Intervention in Short Telomere Syndromes and Murine Models of Telomere Dysfunction, Frontiers in Aging, October 2021, Volumer 2, Article 785171
- Amanda J. Stock et al. Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo, GeroScience, Volume 45, pages 2213–2228, (2023)
- Hector Rodriguez Cetina Biefer et al. Aspects of Tryptophan and Nicotinamide Adenine Dinucleotide in Immunity: A New Twist in an Old Tale, Int J Tryptophan Res. 2017 Jun 14
Recommended dose
Adults take 2 capsules 1 time per day or as advised by a health care practitioner.
Cautions:
Do not use this product if you are pregnant or breastfeeding. Some people may experience gastrointestinal upset and/or diarrhea. Stop use if hypersensitivity/allergy occurs.
Store in dry, cool place away from sunlight.
Do not use if seal is broken. Keep out of reach of children. Keep sealed, store in a cool, dry place at 15–25ºC.
