Unlocking Metabolic Benefits: The Powerful Combination of Berberine TPGS and Metabolix

In the ever-evolving landscape of natural health strategies, understanding the metabolic benefits of specific products can be a game-changer. Starting today you can revolutionize your metabolic health journey with two breakthrough products from Provita Nutrition, Berberine TPGS, and Metabolix.

Both formulas are meticulously crafted with science-backed ingredients and designed to optimize your metabolism, enhance energy levels, and support overall well-being.

Berberine TPGS: Turbocharge Your Insulin Sensitivity

Berberine, a natural compound derived from various plants, has gained recognition as a metabolic powerhouse. However, when combined with Tocophersolan,1 Chitosan,2 and Sodium Caprate3,4 in Provita Berberine TPGS, its effectiveness reaches unprecedented heights.

Berberine has numerous benefits including its ability to regulate blood sugar levels along with hemoglobin (HbA1c) levels,5 lower total cholesterol, LDL cholesterol6 (often referred to as "bad" cholesterol), and triglycerides6 while increasing HDL cholesterol ("good" cholesterol)6 and improve gut microbiota disorders.7

Berberine can also ignite your metabolism due to two key benefits:

1. Enhancing Insulin Sensitivity: One of the key metabolic benefits of Berberine TPGS lies in its ability to activate insulin receptor sites.8 Enhanced insulin sensitivity is a critical factor in managing blood sugar levels and mitigating insulin resistance. When insulin sensitivity improves, your body becomes more efficient at using insulin to transport glucose into cells, reducing the risk of elevated blood sugar and related complications, increasing the signal to burn glucose for energy, and reducing the signal to store calories as fat.7,9

2. AMPK Activation: Berberine TPGS is also a potent activator of AMP-activated protein kinase (AMPK), a cellular energy regulator.10,11 AMPK activation is like flipping a switch that encourages your body to burn fat stores and stimulates glucose metabolism (burning glucose (aka carbohydrates) to produce energy through efficient glucose uptake) and lipid metabolism (burning fat for fuel).12 This can lead to increased energy levels, improved metabolic function, and better weight management.13

Berberine has also been found to inhibit the activity of certain enzymes responsible for fat storage (PAPs),14 inhibit the differentiation and growth of fat cells (adipocytes),15 and promote the recruitment and activation of brown adipose tissue which helps burn calories and reduce weight.16

Metabolix: A Metabolic Powerhouse

Metabolix is a comprehensive blend of natural ingredients carefully selected to complement the metabolic benefits of Berberine TPGS:

Gynostemma pentaphyllum 10:1 Extract (500 mg): This adaptogen supports metabolic efficiency, reduces fatigue, and enhances energy levels. Its role in activating AMPK and supporting weight loss further amplifies its contribution to your metabolic health.17,18

Hesperidin (Citrus sp.) (300 mg): Another powerful AMPK activator, Hesperidin also promotes vascular health and circulation, while also supporting healthy weight loss and improved metabolic function.19,20

Goldenseal 10:1 Extract (Hydrastis canadensis) (200 mg): Goldenseal extract aids digestion and helps maintain steady blood sugar levels, vital for overall metabolic balance. It is also a natural source of Berberine.

Fenugreek 20:1 Extract (Trigonella foenum-graecum) (200 mg): Fenugreek is renowned for promoting healthy blood sugar levels and supporting weight management.21

Cordyceps sinensis 10:1 Extract (100 mg): Cordyceps enhances cellular energy production, providing you with the vitality needed for an active lifestyle. It also includes a natural extract called Cordycepin, a potent AMPK activator that helps improve performance and supports weight loss.22,23

Alpha Lipoic Acid (32 mg): This potent antioxidant safeguards cellular health and supports efficient metabolism.24,25

Vitamin B5 (Calcium Pantothenate) (30 mg):  Vitamin B5 plays a pivotal role in energy metabolism and overall well-being.26

The combination of ingredients in Metabolix not only help regulate blood sugar and stimulate insulin sensitivity, but also are powerful AMPK activators and have been clinically studied to help fat reduction and weight loss.

 

When you combine Berberine TPGS and Metabolix, you're creating a powerhouse protocol for metabolic health:

1. Enhanced Insulin Sensitivity: Berberine TPGS optimizes insulin receptor sites, making your body more responsive to insulin, which can lead to better blood sugar control.

2. AMPK Activation: These two products combined are nature’s most powerful AMPK activators, boosting your cellular energy production and supporting healthy weight management.

3. Comprehensive Support: Metabolix's carefully selected ingredients complement Berberine TPGS, offering a holistic approach to metabolic wellness.

4. Improved Energy Levels: AMPK activation enhances energy production, helping you feel more energetic and vital in your day-to-day activities.

 

The combination of Provita Berberine TPGS and Metabolix can be a game-changing strategy for those looking to optimize their metabolic health. By improving insulin sensitivity and activating AMPK, you're not only supporting better blood sugar control but also taking significant steps toward achieving your weight management goals.

As with any supplement regimen, consult with a healthcare professional to determine the best approach for your individual needs and enjoy the benefits of these remarkable products. Your journey to improved metabolic health starts here!

References:

1. Chen W, Miao YQ, Fan DJ, Yang SS, Lin X, Meng LK, Tang X. Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats. AAPS PharmSciTech. 2011 Jun;12(2):705-11. doi: 10.1208/s12249-011-9632-z. Epub 2011 Jun 3.

2. Chen W, Fan D, Meng L, Miao Y, Yang S, Weng Y, He H, Tang X. Enhancing effects of chitosan and chitosan hydrochloride on intestinal absorption of berberine in rats. Drug Dev Ind Pharm. 2012 Jan;38(1):104-10. doi: 10.3109/03639045.2011.592531. Epub 2011 Jul 20.

3. Lv XY, Li J, Zhang M, Wang CM, Fan Z, Wang CY, Chen L. Enhancement of sodium caprate on intestine absorption and antidiabetic action of berberine. AAPS PharmSciTech. 2010 Mar;11(1):372-82. doi: 10.1208/s12249-010-9386-z. Epub 2010 Mar 17.

4. Fan D, Wu X, Dong W, Sun W, Li J, Tang X. Enhancement by sodium caprate and sodium deoxycholate of the gastrointestinal absorption of berberine chloride in rats. Drug Dev Ind Pharm. 2013 Sep;39(9):1447-56. doi: 10.3109/03639045.2012.723219. Epub 2012 Oct 1.

5. Xie W, Su F, Wang G, Peng Z, Xu Y, Zhang Y, Xu N, Hou K, Hu Z, Chen Y, Chen R. Glucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis. Front Pharmacol. 2022 Nov 16;13:1015045. doi: 10.3389/fphar.2022.1015045.

6. Ju J, Li J, Lin Q, Xu H. Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials. Phytomedicine. 2018 Nov 15;50:25-34. doi: 10.1016/j.phymed.2018.09.212. Epub 2018 Sep 28.

7. Xu X, Yi H, Wu J, Kuang T, Zhang J, Li Q, Du H, Xu T, Jiang G, Fan G. Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. Biomed Pharmacother. 2021 Jan;133:110984. doi: 10.1016/j.biopha.2020.110984. Epub 2020 Nov 10.

8. Yang J, Yin J, Gao H, Xu L, Wang Y, Xu L, Li M. Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients. Evid Based Complement Alternat Med. 2012;2012:363845. doi: 10.1155/2012/363845. Epub 2012 Mar 8.

9. Xie W, Su F, Wang G, Peng Z, Xu Y, Zhang Y, Xu N, Hou K, Hu Z, Chen Y, Chen R. Glucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis. Front Pharmacol. 2022 Nov 16;13:1015045. doi: 10.3389/fphar.2022.1015045.

10. Jin Y, Liu S, Ma Q, Xiao D, Chen L. Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes. Eur J Pharmacol. 2017 Jan 5;794:106-114. doi: 10.1016/j.ejphar.2016.11.037. Epub 2016 Nov 22.

11. Jang J, Jung Y, Seo SJ, Kim SM, Shim YJ, Cho SH, Chung SI, Yoon Y. Berberine activates AMPK to suppress proteolytic processing, nuclear translocation and target DNA binding of SREBP-1c in 3T3-L1 adipocytes. Mol Med Rep. 2017 Jun;15(6):4139-4147. doi: 10.3892/mmr.2017.6513. Epub 2017 Apr 26.

12. Zang Y, Fan L, Chen J, Huang R, Qin H. Improvement of Lipid and Glucose Metabolism by Capsiate in Palmitic Acid-Treated HepG2 Cells via Activation of the AMPK/SIRT1 Signaling Pathway. J Agric Food Chem. 2018 Jul 5;66(26):6772-6781. doi: 10.1021/acs.jafc.8b01831. Epub 2018 Jun 20

13. Tamargo-Gómez I, Mariño G. AMPK: Regulation of Metabolic Dynamics in the Context of Autophagy. Int J Mol Sci. 2018 Nov 29;19(12):3812. doi: 10.3390/ijms19123812.

14. Heidarian E, Rafieian-Kopaei M, Khoshdel A, Bakhshesh M. Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine. Asian Pac J Trop Biomed. 2014 May;4(Suppl 1):S429-35. doi: 10.12980/APJTB.4.2014C474.

15. Hu Y, Davies GE. Berberine inhibits adipogenesis in high-fat diet-induced obesity mice. Fitoterapia. 2010 Jul;81(5):358-66. doi: 10.1016/j.fitote.2009.10.010. Epub 2009 Oct 25.

16. Wu L, Xia M, Duan Y, Zhang L, Jiang H, Hu X, Yan H, Zhang Y, Gu Y, Shi H, Li J, Gao X, Li J. Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans. Cell Death Dis. 2019 Jun 13;10(6):468. doi: 10.1038/s41419-019-1706-y.

17. Nguyen NH, Ha TKQ, Yang JL, et al. Triterpenoids from the genus Gynostemma: Chemistry and pharmacological activities. J Ethnopharmacol. 2021 Mar 25;268:113574.

18. Park SH, Huh TL, Kim SY, et al. Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): a randomized, double-blind, placebo-controlled trial. Obesity (Silver Spring). 2014 Jan;22(1): 63-71.

19. Rizza S, Muniyappa R, Iantorno M, et al. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab. 2011 May;96(5):E782-92.

20. Martinez Noguera FJ, Alcaraz PE, Carlos Vivas J, et al. 8 weeks of 2S-Hesperidin supplementation improves muscle mass and reduces fat in amateur competitive cyclists: randomized controlled trial. Food Funct. 2021 May 11;12(9):3872-82.

21. Shabil M, Bushi G, Bodige PK, Maradi PS, Patra BP, Padhi BK, Khubchandani J. Effect of Fenugreek on Hyperglycemia: A Systematic Review and Meta-Analysis. Medicina (Kaunas). 2023 Jan 27;59(2):248. doi: 10.3390/medicina59020248.

22. Hirsch KR, Smith-Ryan AE, Roelofs EJ, Trexler ET, Mock MG. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. J Diet Suppl. 2017 Jan 2;14(1):42-53. doi: 10.1080/19390211.2016.1203386. Epub 2016 Jul 13.

23. An Y, Li Y, Wang X, Chen Z, Xu H, Wu L, Li S, Wang C, Luan W, Wang X, Liu M, Tang X, Yu L. Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats. Lipids Health Dis. 2018 Dec 6;17(1):276. doi: 10.1186/s12944-018-0910-6.

24. Ansar H, Mazloom Z, Kazemi F, Hejazi N. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J. 2011 Jun;32(6):584-8.

25. Capece U, Moffa S, Improta I, Di Giuseppe G, Nista EC, Cefalo CMA, Cinti F, Pontecorvi A, Gasbarrini A, Giaccari A, Mezza T. Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features. Nutrients. 2022 Dec 21;15(1):18. doi: 10.3390/nu15010018.

26. Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998.